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Teacher Name-:  Smith Date-:  August 1, 2005
Grade Level-:  10-12 Subject-:  Science
Title-:  Genetic Disorders and Genetic Testing Unit-:  The Molecular Basis of Heredity
Period-:  6
Title--: Science
Goal(s)-:   1. Students will become familiar with genetic disorders and genetic testing.
2. Students will understand that a gene may be defective or abnormal and that this may adversely affect the individual physically, mentally, or socially.
3. Students will understand that defective genes may be passed from parents to their offspring and that the parents may not possess the disorder and may be unaware that they carry the defective gene.
Learning Objectives/Performance Indicators-:   1. The student will describe the characteristics of a selected genetic disorder.
2. The student will explain what affects the selected disorder has on the person’s quality of life, by citing at least four (4) examples.
3. The student will express the possible genotypes of the parents and affected offspring for the genetic disorder and predict the probabilities of other offspring having this disorder.
4. The student will explain, using at least two (2) examples, how it is possible for a parent to carry a gene for a genetic disorder and not know that they possess this gene.
5. Based on research, the student will justify an argument, either for or against, genetic testing of potential parents.
6. The student will provide contact information for at least one (1) local organization that can assist the affected person and his or her family. (Students who show early mastery will be expected to provide three (3) local organizations.)
7. The student will present the results of their group research to the class in a 15-20 minute presentation either using PowerPoint software as visual aids.
Purpose / Rationale-:   Genetic disorders are inherited by offspring from their parents. There are several reasons why a potential parent might consider genetic testing and each team will have an opportunity to explore this topic and formulate their opinion on the subject. Then, they will present their argument to the class. A genetic disorder may be caused by one defective gene or another anomaly. Individuals affected with a genetic disorder may face physical, mental, and social challenges. Support groups offer individuals and their family members helpful ways to cope with the disorder and its effects on their lives.
Curriculum Standards-:   The National Science Standards referenced in this lesson include: Content Standard C: Life Science, The Molecular Basis of Heredity Content Standard E: Science and Technology, Understanding About Science and Technology
Teacher Preparation-:   Preparation for this lesson includes familiarity with local, state, and national learning standards. An Internet search will be conducted to gather information on the topic useful web sites will be collected to assist students in completing their assignments.
Materials / Resources-:   • Textbook
• Overhead Projector (with extra light bulb)
• Overhead Transparencies
• Dry Erase Markers / Eraser
• Projector Screen
• Pictures of individuals who possess a genetic disorder and pictures of individuals who carry a gene for a genetic disorder
• Computers with Internet accessibility and Microsoft PowerPoint software
• LCD Projector that connects to the classroom computer
• A printer that is connected to the computers.
Procedures/Methods-:   This is a cooperative learning experience for students that is structured with a guided inquiry. The teacher will provide the information for students to begin their inquiry and will monitor progress as the assignment progresses. Students will be assigned groups to complete this assignment.
Introduction /Motivator-:   Pictures of individuals who have genetic disorders as well as pictures of individuals who “look normal” but carry a gene for a genetic disorder will be passed around the room. Once students begin to look at the photographs, the teacher will ask them what they think. Students will be allowed to express their thoughts about the pictures. What do the pictures mean? What is different about the people in the pictures? Engage in a discussion that gets them thinking about different genetic diseases and how they affect a person’s quality of life. Can some people carry a gene for a disorder, but not express the disorder? This question should stimulate even more discussion.
Demonstration/Exploration-:   For this collaborative learning / guided inquiry lesson, students will complete a WebQuest on genetic disorders. They will be assigned to groups of three or four. This activity will span several days. Each group will agree upon and select a genetic disorder to explore. Upon completion of the WebQuest activity, they will give a short presentation (15-20 min) to the class presenting their findings. There are thousands of genetic disorders that affect humans, some of which can have profound effects on a person's quality of life. Genetic disorders are passed from parents to offspring in the genetic code, and in some cases, a person may be a carrier for a disease and pass it to their children without knowing. Because genetic diseases are usually caused by errors or mutations in the genetic code, it is extremely difficult to cure the condition, and in most cases, doctors can only treat the symptoms. Through your research you will gather information about a specific disorder. You will know how it affects the individual with the disease and how it affects his or her family. This knowledge will help you formulate an opinion on genetic testing of parents prior to conceiving a child. You will be able to assess the benefits and risks of such testing and share that information with your classmates. Guided Practice A list of genetic disorders will be presented to the class. Sample Web sites containing information on a sampling of genetic disorders will be viewed. Search engines, such as Google and Yahoo, may be used to perform searches for information on genetic disorders and genetic testing. The types of information useful for conducting this learning assignment will be covered and explained. Additional sites that have been reviewed will be supplied to the students. Students with special needs may contribute to this project by gathering information from the Internet, working with team members on the presentation, and running the presentation on the computer. Students who excel may be responsible for filtering the information gathered and putting the relevant information into the presentation.
Application-:   Students will be given an assignment (independent practice) that requires them to provide information to the following questions: “What are some genetic disorders?” “What are some of the challenges individuals with this disorder face?” “What can we do to help make their lives more pleasant?” Upon completion, students will be required to present the information to the entire class.
Evaluation/Assessment-:   A rubric will be used to assess the quality of the research and the final presentation.
Accommodation Needs-:   Students who display early mastery may design a survey form that can be handed out to their classmates gathering their opinions on genetic testing. This survey could be handed out upon completion of their group’s presentation.
Teacher Reflection-:   Reflections will be based on the effectiveness of group work, the assignment given and the quality of the final product, and the extent to which students have mastered the key concepts presented in the lesson. Modifications will be made accordingly.